Leidner J, Wong E W, MacGregor D C, Wilson G J
J Biomed Mater Res. 1983 Mar;17(2):229-47. doi: 10.1002/jbm.820170203.
A novel process has been developed for the manufacture of porous vascular grafts from solutions or melts of polymers. It allows the manufacture of grafts with controllable porosity, pore size, and mechanical properties. In this process, the polymer melt or polymer solution is extruded through fine orifices; the fibers are then stretched and wound on a rotating mandril. Fiber-fiber bonding takes place, resulting in the formation of stable porous tubes. The effects of the process variables on the physical properties of the resulting graft have been studied and preliminary in vivo evaluation in dogs has demonstrated graft patency with a thin, stable neointima in both small (4 mm) and large (10 mm) caliber configurations.
已开发出一种新工艺，用于由聚合物溶液或熔体制造多孔血管移植物。它能够制造出孔隙率、孔径和机械性能可控的移植物。在该工艺中，将聚合物熔体或聚合物溶液通过细孔挤出；然后将纤维拉伸并缠绕在旋转的心轴上。纤维与纤维之间发生粘结，从而形成稳定的多孔管。已研究了工艺变量对所得移植物物理性能的影响，并且在犬类动物中的初步体内评估表明，在小口径（4毫米）和大口径（10毫米）配置中，移植物均具有通畅性，且内膜薄而稳定。
