Sośnierz M, Kita I, Kita K
Med Pr. 1977;28(2):91-7.
The animals were exposed to the shortened chronic poisoning with "Karbafos" in doses 20, 70, 250, and 850 ppm adminstered in fodder during 13 weeks. After the end of experiment, the animals were killed and their organs weighed. In the collected specimens, prepared histologically, were found the increase of the kidney mass and many nonspecific pathomorphotic changes. The pulmonary edema, parenchymatous degeneration in heart, kidneys and liver are--according to the authors--directly connected with "Karbafos" action. The intensification of changes was bound with the size of applied dose of preparation. The investigations allowed to fix the highest tolerance dose of "Karbafos" amounting to 20 ppm.
这些动物在13周内通过饲料摄入剂量为20、70、250和850 ppm的“杀螟硫磷”进行缩短的慢性中毒实验。实验结束后，将动物处死并对其器官称重。在组织学制备的采集标本中，发现肾脏重量增加以及许多非特异性病理形态学变化。据作者称，肺水肿、心脏、肾脏和肝脏的实质变性与“杀螟硫磷”的作用直接相关。变化的加剧与制剂施用剂量的大小有关。这些研究确定了“杀螟硫磷”的最高耐受剂量为20 ppm。
