Kavanagh K T, McCabe B F
Laryngoscope. 1983 May;93(5):649-53. doi: 10.1002/lary.1983.93.5.649.
In contrast to parenteral neomycin, which may result in severe and progressive ototoxicity, oral neomycin has been widely used for 25 years, and its index of safety has been regarded as high. Ototoxicity is viewed as an uncommon complication of oral neomycin most likely to occur in patients with renal failure or gastrointestinal inflammation. Two cases of ototoxicity resulting from oral neomycin are presented. Serial audiometric and neomycin blood level testing are suggested as a means of auditory monitoring in patients receiving the drug. A review of experience with oral vancomycin indicates that this drug has not been shown to cause ototoxicity.
与可能导致严重且进行性耳毒性的胃肠外新霉素不同，口服新霉素已广泛使用25年，其安全指数一直被认为很高。耳毒性被视为口服新霉素一种不常见的并发症，最有可能发生于肾衰竭或胃肠道炎症患者。本文报告了2例口服新霉素导致耳毒性的病例。建议对接受该药治疗的患者进行系列听力测定和新霉素血药浓度检测，作为听觉监测手段。对口服万古霉素经验的回顾表明，尚未证实该药会导致耳毒性。
