Aravanis C
Prev Med. 1983 Jan;12(1):16-9. doi: 10.1016/0091-7435(83)90163-9.
This article is based on the follow-up of 9,182 men from 13 cohorts of five European countries (Finland, Greece, Italy, Holland, and Yugoslavia). Its purpose is to explore the associations of known risk factors for coronary heart disease (CHD). A significant positive association was found between age and 10-year mortality from CHD (10-MCHD), between systolic blood pressure (SBP) and 10-MCHD (steeper for the Finns than for men from Mediterranean countries), and between serum cholesterol and 10-MCHD (more pronounced in northern than southern European men). Age-standardized 10-MCHD was found to increase with degree of smoking; the regression slope of this correlation was steeper for men from northern than from southern Europe. Although death from all causes tended to be inversely related to relative body weight, no consistent evidence of a relation between relative body weight or body fatness and CHD was found. Incidence rate of CHD was not consistently related to physical activity characteristics of the groups. Resting pulse rate was an important risk factor for all causes of death in 10 years, but of less consequence for MCHD. Regression slopes were steeper for northern than for southern Europeans. Vital capacity was a significant risk factor for MCHD for Italian but not for Finnish, Greek, or Serbian men. The 10-year adjusted MCHD was correlated with total fat in the diet; the correlation with saturated fatty acids was much more significant.
本文基于对来自五个欧洲国家（芬兰、希腊、意大利、荷兰和南斯拉夫）13个队列的9182名男性的随访研究。其目的是探究冠心病（CHD）已知危险因素之间的关联。研究发现，年龄与冠心病10年死亡率（10-MCHD）之间存在显著正相关，收缩压（SBP）与10-MCHD之间存在显著正相关（芬兰人比地中海国家男性的相关性更强），血清胆固醇与10-MCHD之间存在显著正相关（北欧男性比南欧男性更为明显）。年龄标准化的10-MCHD随吸烟程度增加而升高；这种相关性的回归斜率在北欧男性中比在南欧男性中更陡。尽管全因死亡往往与相对体重呈负相关，但未发现相对体重或体脂与冠心病之间存在一致的关联证据。冠心病发病率与各群体的身体活动特征之间没有一致的关联。静息心率是10年内所有死因的重要危险因素，但对冠心病10年死亡率的影响较小。北欧人的回归斜率比南欧人更陡。肺活量是意大利男性冠心病10年死亡率的显著危险因素，但对芬兰、希腊或塞尔维亚男性则不然。调整后的冠心病10年死亡率与饮食中的总脂肪相关；与饱和脂肪酸的相关性更为显著。
