维生素K缺乏及经丁基羟基甲苯（BHT）处理的雄性大鼠肝脏和粪便中的维生素K含量

Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats.

作者信息

Suzuki H, Nakao T, Hiraga K

出版信息

Toxicol Appl Pharmacol. 1983 Jan;67(1):152-5. doi: 10.1016/0041-008x(83)90253-3.

Abstract

Vitamin K content of liver and feces from male rats fed diets containing butylated hydroxytoluene (BHT) was estimated by a chick bioassay method to investigate the mechanism of BHT-induced decreases in the activities of vitamin K-dependent clotting factors. The concentration of vitamin K in the liver of rats receiving BHT was reduced as compared to that of control rats. Conversely, the concentration of vitamin K in the feces from rats receiving BHT increased more than that from control rats. The vitamin K deficiency induced by BHT might be due to effects of BHT on absorption and excretion of vitamin K.

摘要

采用雏鸡生物测定法估算了喂食含丁基羟基甲苯（BHT）日粮的雄性大鼠肝脏和粪便中的维生素K含量，以研究BHT导致维生素K依赖凝血因子活性降低的机制。与对照大鼠相比，摄入BHT的大鼠肝脏中维生素K浓度降低。相反，摄入BHT的大鼠粪便中维生素K浓度比对照大鼠粪便中的增加得更多。BHT诱导的维生素K缺乏可能是由于BHT对维生素K吸收和排泄的影响。