Lemeshko V V, Nikitchenko Iu V, Kaliman P A
Ukr Biokhim Zh (1978). 1983 Mar-Apr;55(2):206-9.
Thyroxine and actinomycin D evoke activation of enzymatic peroxide oxidation of membrane lipids in the liver mitochondria and microsomes 24 hours after their separate or combined administration to Wistar males rats. In young animals the thyroxine effect is less pronounced than in old ones. Activation of peroxidation of membrane lipids with thyroxine or actinomycin D is not additive. Thyroxine had no essential influence on the glutathione-S-transferase activity of mitochondrial and postmitochondrial fractions of liver homogenates which is higher in old animals.
对雄性Wistar大鼠单独或联合给予甲状腺素和放线菌素D 24小时后，可引起肝线粒体和微粒体中膜脂的酶促过氧化反应激活。在幼龄动物中，甲状腺素的作用不如老龄动物明显。甲状腺素或放线菌素D对膜脂过氧化的激活作用并非相加性的。甲状腺素对肝匀浆线粒体和线粒体后组分中的谷胱甘肽-S-转移酶活性没有实质性影响，而老龄动物的该酶活性较高。
