Reid J, Kennedy R D, Caird F I
Age Ageing. 1983 Feb;12(1):29-37. doi: 10.1093/ageing/12.1.29.
Digoxin elimination phase kinetics have been studied in 24 hospital in-patients (mean age 79 years), six of whom showed no evidence of digoxin toxicity. The others, with suspected toxicity, have been grouped according to the nature of the drug effects observed. Renal function, digoxin elimination half-life, apparent volume of digoxin distribution, and notional body content of digoxin have been compared between the groups. Apart from two hyperthyroid patients, the volumes of distribution averaged 6.1 1/kg. Toxic patients tended to have lower creatinine clearances, longer digoxin half-lives, and higher body contents of digoxin than the nontoxic, but the highest body contents were found in those with systemic toxicity. Thyrotoxicosis increases the apparent volume of digoxin distribution in the elderly.
对24名住院患者（平均年龄79岁）的地高辛消除相动力学进行了研究，其中6人未表现出地高辛中毒迹象。其他疑似中毒的患者则根据观察到的药物效应性质进行分组。比较了各组之间的肾功能、地高辛消除半衰期、地高辛分布表观容积和地高辛理论体内含量。除两名甲状腺功能亢进患者外，分布容积平均为6.1升/千克。中毒患者的肌酐清除率往往低于未中毒患者，地高辛半衰期更长，体内地高辛含量更高，但全身中毒患者的体内含量最高。甲状腺毒症会增加老年人地高辛的分布表观容积。
