Krawiec J, Odes H S, Schwartz B, Lamprecht S A
Am J Gastroenterol. 1983 May;78(5):272-5.
Acid secretion was monitored in five duodenal ulcer patients using intragastric glass pH electrodes located in the gastric body and antrum under basal conditions and after the administration of cimetidine. It was shown that differences exist between the body and antral pH in the basal state and in the response to cimetidine. The basal hydrogen ion concentration (mean +/- SEM, mmol/l) in the body, 25.97 +/- 5.03, exceeded that in the antrum, 10.59 +/- 6.44 (p less than 0.05). After cimetidine, the pH rose to 3.5 at both electrodes, this stage being shorter in the antrum (16 min) than body (54 min) (p less than 0.0125). During the next stage the pH rose above 3.5 and the hydrogen ion concentration (mean +/- SEM, mmol/l) was very low in both the body, 0.05 +/- 0.01 (p less than 0.0005 compared to basal) and antrum, 0.08 +/- 0.05 (p less than 0.05 compared to basal). Recovery to basal pH levels occurred more quickly in the body than antrum. Intragastric pH-metry offers a reliable method for studying the mode of action of pharmacological agents on the stomach and contributes information not made available by routine gastric analysis.
使用置于胃体和胃窦的胃内玻璃pH电极，在基础状态及给予西咪替丁后，对5例十二指肠溃疡患者的胃酸分泌进行了监测。结果显示，基础状态下以及对西咪替丁反应时，胃体和胃窦的pH存在差异。胃体的基础氢离子浓度（平均值±标准误，mmol/L）为25.97±5.03，超过胃窦的10.59±6.44（p<0.05）。给予西咪替丁后，两个电极处的pH均升至3.5，此阶段在胃窦持续时间（16分钟）短于胃体（54分钟）（p<0.0125）。在下一阶段，pH升至3.5以上，胃体和胃窦的氢离子浓度（平均值±标准误，mmol/L）均非常低，胃体为0.05±0.01（与基础状态相比p<0.0005），胃窦为0.08±0.05（与基础状态相比p<0.05）。胃体恢复到基础pH水平的速度比胃窦更快。胃内pH测定为研究药物对胃的作用方式提供了一种可靠的方法，并提供了常规胃液分析无法获得的信息。
