Holmes P A, Pritchard A B, Kirschman J C
Toxicology. 1978 Jun;10(2):185-93. doi: 10.1016/0300-483x(78)90068-9.
Rat fed carmoisine (C.I. (1956) No. 14720) at 0.35, 0.8 or 2.0% in the diet for 52 weeks showed no adverse effects of the dye when compared to control animals. Mortality, weight gain, hematological values and relative organ weights were the same in control and treated animals. There was no increase in tumor incidence due to carmoisine treatment. Male rats fed 2.0% carmoisine showed an increased incidence of several mild subclinical conditions (minimal bronchitis and tracheal inflammation). Because of this occurrence, the maximum no-effect level after 1 year exposure appears to be 0.8%, equivalent to a daily intake of approx. 400 mg/kg.
给大鼠喂食含0.35%、0.8%或2.0%胭脂红（C.I.（1956）编号14720）的饲料，持续52周，与对照动物相比，未显示出该染料的不良影响。对照动物和处理动物的死亡率、体重增加、血液学值和相对器官重量相同。胭脂红处理未导致肿瘤发生率增加。喂食2.0%胭脂红的雄性大鼠出现几种轻度亚临床病症（轻度支气管炎和气管炎症）的发生率增加。由于出现这种情况，1年暴露后的最大无作用水平似乎为0.8%，相当于每日摄入量约400毫克/千克。
