胭脂红对大鼠的多代繁殖研究。

Multigeneration reproduction studies with carmoisine in rats.

作者信息

Holmes P A, Pritchard A B, Kirschman J C

出版信息

Toxicology. 1978 Jun;10(2):169-83. doi: 10.1016/0300-483x(78)90067-7.

Abstract

Carmoisine (C.I. (1956) No. 14720) was fed at levels of 0, 0.35, 0.8 and 2.0% in the diet of rats throughout a multigeneration reproduction study. The dye had not untoward effects on reproduction capacity of any of the generations studied. Fertility, lactation and viability indices of all groups fed carmoisine did not differ significantly from controls at any stage of the study. These results indicate a maximum no-effect level of 2% in the diet. Data from an additional nine-week feeding study (dietary levels were 0, 2, 4, 6 and 8%) suggest that the no-effect level may in fact be even higher since 4% carmoisine in the diet was tolerated without evidence of overt toxicity.

摘要

在一项多代繁殖研究中，给大鼠喂食含0%、0.35%、0.8%和2.0%胭脂红（C.I. (1956) 编号14720）的饲料。该染料对所研究的任何一代的繁殖能力均无不良影响。在研究的任何阶段，所有喂食胭脂红的组的生育力、泌乳力和活力指数与对照组相比均无显著差异。这些结果表明饲料中最大无作用水平为2%。另一项为期九周的喂养研究（饲料水平为0%、2%、4%、6%和8%）的数据表明，无作用水平实际上可能更高，因为饲料中4%的胭脂红可被耐受，且无明显毒性迹象。