不同铁负载量的含铁蛋白组分对脂质过氧化的影响。
Effect of ferritin-containing fractions with different iron loading on lipid peroxidation.
作者信息
Gutteridge J M, Halliwell B, Treffry A, Harrison P M, Blake D
出版信息
Biochem J. 1983 Feb 1;209(2):557-60. doi: 10.1042/bj2090557.
Abstract
Ferritin-containing fractions with different degrees of iron loading were prepared. All ferritin fractions stimulated the peroxidation of bovine brain phospholipid liposomes, as measured by the formation of thiobarbituric acid-reactive material. This stimulation was increased in the presence of ascorbate. Iron salts of equivalent concentration to those of the ferritin fractions were more stimulatory to lipid peroxidation at the higher iron concentrations. None of the fractions inhibited ascorbate-dependent peroxidation in the presence of added iron salts.
摘要
制备了具有不同铁负载程度的含铁蛋白组分。通过硫代巴比妥酸反应性物质的形成来测定，所有铁蛋白组分均刺激牛脑磷脂脂质体的过氧化。在抗坏血酸存在的情况下，这种刺激作用增强。与铁蛋白组分浓度相当的铁盐在较高铁浓度下对脂质过氧化的刺激作用更强。在添加铁盐的情况下，没有一个组分抑制抗坏血酸依赖性过氧化。
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