Hyams J S
Gastroenterology. 1983 Jan;84(1):30-3.
Sorbitol, a polyalcohol sugar, is the sweetener in most "sugar-free" products and may produce an osmotic diarrhea if ingested in large amounts (20-50 g). Whether or not smaller amounts of ingested sorbitol may be associated with other symptoms characteristic of carbohydrate malabsorption has not been determined. Using breath hydrogen analysis, the absorption of 5, 10, and 20 g of sorbitol was studied in 7 healthy volunteers. In a majority of subjects, ingestion of as little as 5 g sorbitol was associated with a significant increase in breath hydrogen concentration. Most subjects experienced mild gastrointestinal distress (gas, bloating) after 10 g and severe symptoms (cramps, diarrhea) after 20 g. These data suggest that the evaluation of patients with "functional" gastrointestinal complaints should include careful inquiry into the use of products containing sorbitol.
山梨醇是一种多元醇糖，是大多数“无糖”产品中的甜味剂，如果大量摄入（20 - 50克）可能会导致渗透性腹泻。少量摄入山梨醇是否会与碳水化合物吸收不良的其他特征性症状相关联尚未确定。通过呼气氢分析，在7名健康志愿者中研究了5克、10克和20克山梨醇的吸收情况。在大多数受试者中，摄入低至5克山梨醇就会导致呼气氢浓度显著升高。大多数受试者在摄入10克后出现轻度胃肠道不适（胀气、腹胀），在摄入20克后出现严重症状（痉挛、腹泻）。这些数据表明，对有“功能性”胃肠道不适的患者进行评估时应仔细询问其对含山梨醇产品的使用情况。
