Morgenstern L, Shemen L, Allen W, Amodeo P, Michel S L
Arch Surg. 1983 Jan;118(1):62-4. doi: 10.1001/archsurg.1983.01390010048011.
In 30 cases of colonic neoplasia associated with melanosis coli, proliferating or neoplastic colonic epithelium was notable within the melanotic colons by virtue of a striking absence of pigmentation. Microscopically this characteristic was found to be due to an absence or diminution of pigment-laden macrophages in the lamina propria underlying such lesions. Therefore, the absence of pigment-laden macrophages can be considered a marker for abnormally proliferating epithelium. This characteristic may denote a cellular or humoral change mediated by macrophages in association with neoplastic epithelium.
在30例伴有结肠黑变病的结肠肿瘤病例中，黑色素沉着的结肠内增殖性或肿瘤性结肠上皮因明显缺乏色素沉着而显著。显微镜检查发现，这一特征是由于此类病变下方固有层中含色素巨噬细胞的缺失或减少所致。因此，含色素巨噬细胞的缺失可被视为异常增殖上皮的一个标志物。这一特征可能表明巨噬细胞介导的与肿瘤上皮相关的细胞或体液变化。
