Viceconte G
Gut. 1983 Jan;24(1):20-7. doi: 10.1136/gut.24.1.20.
The effects of ethanol, given either intragastrically or intravenously, on the sphincter of Oddi was evaluated by endoscopic manometry. In 12 subjects intragastric ethanol (150 ml of 32%) was given over 10 minutes. In five control subjects saline solution (150 ml of 0.9%) was given intragastrically instead of ethanol. In five other subjects ethanol was infused intravenously (6 ml/kg of 10%) for 36 minutes. Ethanol given intragastrically produced a significant inhibitory effect on sphincter of Oddi pressure. Peak pressure fell from a control value of 75.7 +/- 26.35 mmHg to 39 +/- 15.39 mmHg (p less than 0.001) at 35 minutes. Basal pressure fell from a control value of 30.17 +/- 19.47 mmHg to 11.83 +/- 6.35 mmHg (p less than 0.01) at 35 minutes. Wave height fell from a control value of 41.33 +/- 15.4 mmHg to 27.16 +/- 11.25 mmHg (p less than 0.02) at 35 minutes. No effects on sphincter of Oddi wave frequency were observed. No significant modifications of sphincter motor activity were observed after intragastric saline infusion. Ethanol given intravenously also produced an appreciable inhibitory effect on sphincter of Oddi pressure, without affecting its wave frequency.
通过内镜测压法评估了经胃内或静脉给予乙醇对Oddi括约肌的影响。在12名受试者中，在10分钟内给予胃内乙醇（150毫升32%的乙醇）。在5名对照受试者中，胃内给予的是盐溶液（150毫升0.9%的盐水）而非乙醇。在另外5名受试者中，静脉输注乙醇（6毫升/千克10%的乙醇），持续36分钟。经胃内给予乙醇对Oddi括约肌压力产生了显著的抑制作用。在35分钟时，峰值压力从对照值75.7±26.35毫米汞柱降至39±15.39毫米汞柱（p<0.001）。基础压力在35分钟时从对照值30.17±19.47毫米汞柱降至11.83±6.35毫米汞柱（p<0.01）。波高在35分钟时从对照值41.33±15.4毫米汞柱降至27.16±11.25毫米汞柱（p<0.02）。未观察到对Oddi括约肌波频率的影响。胃内输注盐水后未观察到括约肌运动活动的显著改变。静脉给予乙醇也对Oddi括约肌压力产生了明显的抑制作用，且不影响其波频率。
