Kenyon G S, Ansell I F, Carter D C
Gut. 1977 Aug;18(8):631-5. doi: 10.1136/gut.18.8.631.
The histamine H2-receptor antagonist, cimetidine, when given topically or parenterally, did not affect net luminal Na+ gain or net luminal H+ loss in vagally-denervated pouches of antrectomised dogs. Cimetidine did not affect disruption of the mucosal barrier by 5 mmol/l or 20 mmol/l sodium taurocholate.
组胺H2受体拮抗剂西咪替丁,经局部或胃肠外给药时,对切除胃窦的犬迷走神经切断后的胃囊管腔内净钠增加或净氢离子减少均无影响。西咪替丁对5毫摩尔/升或20毫摩尔/升牛磺胆酸钠引起的黏膜屏障破坏也无影响。