Gelberman R H, Vande Berg J S, Lundborg G N, Akeson W H
J Bone Joint Surg Am. 1983 Jan;65(1):70-80.
Healing canine flexor tendons were treated with either total immobilization and were studied by light, scanning, and transmission electron microscopy at ten, twenty-one , and forty-two days. The immobilized tendons healed by ingrowth of connective tissue from the digital sheath and cellular proliferation of the endotenon. The ingrowth of reparative tissue from the digital sheath overwhelmed the epitenon response. At the ultrastructural level, collagen resorption was prominent whereas protein synthesis was limited. This was observed at all study-intervals. In contrast, the mobilized tendons healed by proliferation and migration of cells from the epitenon. Ingrowth of reparative tissue from the tendon sheath was notably lacking in this group. The epitenon cells exhibited greater cellular activity and collagen production at each interval compared with cells of the immobilized repairs.
对正在愈合的犬屈肌腱进行完全固定处理，并在第10天、21天和42天通过光学显微镜、扫描电子显微镜和透射电子显微镜进行研究。固定的肌腱通过来自指腱鞘的结缔组织长入和腱内膜的细胞增殖而愈合。来自指腱鞘的修复组织长入超过了腱外膜的反应。在超微结构水平上，胶原吸收显著，而蛋白质合成受限。在所有研究间隔均观察到这种情况。相比之下，活动的肌腱通过腱外膜细胞的增殖和迁移而愈合。该组明显缺乏来自腱鞘的修复组织长入。与固定修复的细胞相比，腱外膜细胞在每个间隔都表现出更大的细胞活性和胶原蛋白产生。
