Hayek A, Bryant P D, Woodside W F
Metabolism. 1983 Jan;32(1):1-3. doi: 10.1016/0026-0495(83)90146-4.
Hypernatremic states, often the result of hypothalamic osmoreceptor dysfunction in humans, are sometimes accompanied by hyperlipemia. To investigate whether hypernatremia could cause hyperlipemia we induced hypernatremia in three groups of rats with their respective controls: Group A rats received hypertonic saline alone intragastrically; group B animals were pair-fed and tap water was substituted for hypertonic saline in the treated group; in group C the rats were again fed intragastrically with a liquid diet mixed with hypertonic saline. Rats receiving excess salt had mean serum Na+ concentrations exceeding 159 mmoles/l. While the serum triglyceride values were significantly higher in all hypernatremic rats, hepatic triglyceride content was greater only in group C rats (p less than .01). Serum free fatty acids and ketone bodies were also higher in group C rats (p less than .01) as compared to controls. These data suggest that hypernatremia by itself leads to hyperlipemia and a fatty liver.
高钠血症状态在人类中常因下丘脑渗透压感受器功能障碍所致，有时会伴有高脂血症。为研究高钠血症是否会导致高脂血症，我们将三组大鼠诱导为高钠血症，并分别设置相应对照组：A组大鼠仅经胃内给予高渗盐水；B组动物采用配对喂养，在处理组中用自来水替代高渗盐水；C组大鼠再次经胃内给予混合高渗盐水的流质饮食。摄入过量盐分的大鼠血清钠平均浓度超过159毫摩尔/升。虽然所有高钠血症大鼠的血清甘油三酯值均显著升高，但仅C组大鼠的肝脏甘油三酯含量更高（p小于0.01）。与对照组相比，C组大鼠的血清游离脂肪酸和酮体也更高（p小于0.01）。这些数据表明，高钠血症本身会导致高脂血症和脂肪肝。
