Gollapudi S V, Gupta A, Thadepalli H, Perez A
Department of Pathology, Charles R. Drew University, Los Angeles, California 90059.
Infect Immun. 1988 Sep;56(9):2369-72. doi: 10.1128/iai.56.9.2369-2372.1988.
The role of cell-free soluble factors (lymphokines) derived from mitogen-activated splenic cells of mice previously immunized against Bacteroides fragilis was evaluated in the treatment of B. fragilis intra-abdominal abscess (IAA). Neither clindamycin nor lymphokines alone were effective against an established B. fragilis IAA, but the combination of clindamycin and lymphokines decreased the abscess size and bacterial counts in the majority of animals. This suggests that the synergy of lymphokines with clindamycin effects cure of IAA caused by B. fragilis and that lymphokines might have an application as adjuncts to conventional antimicrobial therapy in this setting.
评估了来自先前针对脆弱拟杆菌免疫的小鼠经丝裂原激活的脾细胞产生的无细胞可溶性因子（淋巴因子）在治疗脆弱拟杆菌腹腔内脓肿（IAA）中的作用。单独使用克林霉素或淋巴因子对已形成的脆弱拟杆菌IAA均无效，但克林霉素和淋巴因子的联合使用在大多数动物中减小了脓肿大小并降低了细菌数量。这表明淋巴因子与克林霉素的协同作用可治愈由脆弱拟杆菌引起的IAA，并且在这种情况下淋巴因子可能作为传统抗菌治疗的辅助手段应用。
