Eisenhofer G, Lambie D G, Johnson R H
Br J Clin Pharmacol. 1985 Dec;20(6):684-7. doi: 10.1111/j.1365-2125.1985.tb05129.x.
The acute effects of ethanol on circulatory responses to isoprenaline and atropine were investigated in 21 and 15 normal male subjects respectively. Each subject acted as his own control by participating twice, once after consumption of ethanol (1.0 ml kg-1, 20% v/v in orange juice) and once after orange juice. Ethanol increased baseline heart rate and forearm blood flow, but had no effect on heart rate and forearm blood flow responses to isoprenaline, or on heart rate responses to atropine. Baseline blood pressure and blood pressure responses to isoprenaline were also unaffected by ethanol. It is concluded that acute ethanol ingestion has no physiologically significant effect on beta-adrenoceptor responsiveness as assessed by the cardiovascular responses to bolus doses of isoprenaline.
分别在21名和15名正常男性受试者中研究了乙醇对异丙肾上腺素和阿托品循环反应的急性影响。每位受试者均参与两次实验，一次是在饮用乙醇（1.0毫升/千克，橙汁中20% v/v）后，另一次是在饮用橙汁后，以此作为自身对照。乙醇使基础心率和前臂血流量增加，但对异丙肾上腺素引起的心率和前臂血流量反应或阿托品引起的心率反应没有影响。乙醇对基础血压和异丙肾上腺素引起的血压反应也无影响。结论是，通过对大剂量异丙肾上腺素的心血管反应评估，急性摄入乙醇对β-肾上腺素能受体反应性没有生理上的显著影响。
