Dohi S
Crit Care Med. 1983 Jun;11(6):434-7. doi: 10.1097/00003246-198306000-00008.
Although severe pulmonary edema is encountered occasionally in patients needing CPR, there has been no definitive description on the mortality and morbidity of pulmonary edema after CPR. The author experienced severe pulmonary edema after standard CPR in 20 of 71 patients who suffered sudden, unexpected cardiac arrest and regained heart function by CPR. The varied onset of pulmonary edema, which may have developed when massive pink frothy secretions exited from the endotracheal tube, ranged from a few minutes to 45 min after the re-establishment of heart beat. These 20 patients showed a significantly higher P(A-a)O2, insignificant lower plasma protein concentrations, and high plasma osmolarities as compared with those who did not develop pulmonary edema. Only 2 patients with pulmonary edema survived. During CPR, many factors could cause pulmonary edema, including external cardiac massage (ECM), administration or release of catecholamines, hypoxia, acidosis, overhydration, etc. This study indicates that patients who need CPR have a high likelihood of developing pulmonary edema.
尽管在需要心肺复苏(CPR)的患者中偶尔会遇到严重肺水肿,但关于心肺复苏后肺水肿的死亡率和发病率尚无明确描述。作者在71例突发意外心脏骤停并通过心肺复苏恢复心功能的患者中,有20例在标准心肺复苏后出现了严重肺水肿。肺水肿的发作时间各异,从心跳恢复后的几分钟到45分钟不等,表现为大量粉红色泡沫样分泌物从气管插管中喷出。与未发生肺水肿的患者相比,这20例患者的肺泡-动脉血氧分压差(P(A-a)O2)显著升高,血浆蛋白浓度无明显降低,血浆渗透压升高。肺水肿患者中仅2例存活。在心肺复苏期间,许多因素可导致肺水肿,包括体外心脏按压(ECM)、儿茶酚胺的应用或释放、缺氧、酸中毒、补液过多等。本研究表明,需要心肺复苏的患者发生肺水肿的可能性很高。