[Interrelationship between the activity of cholinergic processes and catecholamine metabolism in botulin poisoning].

Reversible inhibition of cholinergic processes in cats after pancreatectomy was accompanied by decreased urinary excretion of adrenaline, increased excretion of vanilyl mandelic acid, exhaustion of catecholamine stores in adrenal glands and increased content of noradrenaline in some tissues. Similar alterations occurred in the paralytic step of botulinic intoxication. Metabolism of catecholamines was much more distinctly impaired in previously pancreatectomized animals after development of botulinic and tetanic neurointoxications, which were accompanied by irreversible inhibition of acetylcholine liberation in myoneural synapses. Impairments of catecholamine metabolism were manifested in a decrease in total content of the substances studied in various tissues.