Chesnokova N P
Vopr Med Khim. 1978 Jul-Aug;24(4):490-5.
Reversible inhibition of cholinergic processes in cats after pancreatectomy was accompanied by decreased urinary excretion of adrenaline, increased excretion of vanilyl mandelic acid, exhaustion of catecholamine stores in adrenal glands and increased content of noradrenaline in some tissues. Similar alterations occurred in the paralytic step of botulinic intoxication. Metabolism of catecholamines was much more distinctly impaired in previously pancreatectomized animals after development of botulinic and tetanic neurointoxications, which were accompanied by irreversible inhibition of acetylcholine liberation in myoneural synapses. Impairments of catecholamine metabolism were manifested in a decrease in total content of the substances studied in various tissues.
胰腺切除术后猫体内胆碱能过程的可逆性抑制伴随着肾上腺素尿排泄减少、香草扁桃酸排泄增加、肾上腺中儿茶酚胺储备耗竭以及某些组织中去甲肾上腺素含量增加。肉毒中毒的麻痹阶段也出现了类似的变化。在肉毒中毒和破伤风神经中毒发生后，先前胰腺切除的动物体内儿茶酚胺代谢受到的损害更为明显，同时伴有神经肌肉突触中乙酰胆碱释放的不可逆抑制。儿茶酚胺代谢的损害表现为各种组织中所研究物质的总含量降低。
