Alwmark A, Bengmark S, Christensen P, Gullstrand P, Schalén C
Eur Surg Res. 1983;15(2):92-6. doi: 10.1159/000128338.
22 male Sprague-Dawley rats were divided into two groups, of which group I received methylcellulose and group II saline intraperitoneally for 12 weeks. After ligation of the splenic artery of the animals in group I and sham operation of the rats in group II, the injections were continued for a further 9 weeks. At the operation, the group I animals all showed signs of hypersplenism with anemia, and leuko- and thrombocytopenia. The platelet counts normalized after the operation, a marked leukocytosis developed and the anemia was further aggravated. At the end of the study, the animals were challenged with 4 x 10(6) colony-forming units of pneumococci type 1, resulting in deaths of 11 of 12 animals in group I, in contrast to survival of all 10 rats in group II (p = 0.000017).
22只雄性Sprague-Dawley大鼠被分为两组，其中第一组腹腔注射甲基纤维素，第二组腹腔注射生理盐水，持续12周。在第一组动物结扎脾动脉以及第二组大鼠进行假手术后，继续注射9周。手术时，第一组动物均表现出脾功能亢进伴贫血、白细胞减少和血小板减少的症状。术后血小板计数恢复正常，出现明显的白细胞增多，贫血进一步加重。在研究结束时，用4×10(6)个1型肺炎球菌菌落形成单位攻击动物，结果第一组12只动物中有11只死亡，而第二组10只大鼠全部存活（p = 0.000017）。
