Alwmark A, Bengmark S, Börjesson B, Gullstrand P
Eur Surg Res. 1982 Sep-Oct;14(5):322-32. doi: 10.1159/000128305.
Methylcellulose injected intraperitoneally into rats proved to give a splenomegaly combined with anemia and thrombocytopenia. The white blood cell count did not change during the treatment. The splenic parenchyma of the hypersplenic rats was then reduced by resection or splenic artery ligation to a different extent. The peripheral blood cell count was normalized after a one-third resection, whereas a more-than-two-thirds reduction of the splenic parenchyma caused infective complications in many rats. It was thus possible to treat the 'secondary hypersplenism' in the rat by a partial reduction of the splenic parenchyma and to avoid total splenectomy, much undesired with new immunologic knowledge.
向大鼠腹腔内注射甲基纤维素可导致脾肿大，并伴有贫血和血小板减少。治疗期间白细胞计数未发生变化。然后，通过切除或结扎脾动脉，不同程度地减少脾功能亢进大鼠的脾实质。切除三分之一的脾后，外周血细胞计数恢复正常，而脾实质减少超过三分之二则在许多大鼠中引发感染并发症。因此，通过部分减少脾实质来治疗大鼠的“继发性脾功能亢进”成为可能，并且避免了全脾切除术，鉴于新的免疫学知识，全脾切除术是非常不可取的。
