Molinari J L, Meza R, Suárez B, Palacios S, Tato P, Retana A
Exp Parasitol. 1983 Jun;55(3):340-57. doi: 10.1016/0014-4894(83)90031-0.
Protection was induced in hogs against Taenia solium cysticercosis using an immunogenic complex obtained from its larval "bladder worm" form, Cysticercus cellulosae. Immunoelectrophoresis revealed that this complex contained at least eight antigens. In immunized hogs a total of 71 (mean 11.8) cysticerci were found, whereas in the control animals 397 (mean 74.9) were found. Histopathological studies showed that more than 40% of larvae obtained from immunized hogs were completely destroyed and the others were seen in various stages of degeneration. Eosinophils and mononuclear cells were observed infiltrating the internal structures of the larvae. Intense granulomatous reactions of eosinophils, lymphocytes, macrophages, epithelioid cells, plasma cells, and fibroblasts surrounded the larvae. Larvae from control hogs were intact and surrounded by a small inflammatory reaction. The cellular response was measured by the macrophage migration inhibition test, which was higher in immunized hogs when compared with control animals, either before the infection with T. solium eggs or before slaughter. No significant difference was found in the humoral response of immunized and control hogs.
利用从猪带绦虫幼虫“囊尾蚴”形式即猪囊尾蚴获得的免疫原性复合物，在猪身上诱导出了针对猪带绦虫囊尾蚴病的保护作用。免疫电泳显示该复合物至少含有八种抗原。在免疫的猪中总共发现了71个（平均11.8个）囊尾蚴，而在对照动物中发现了397个（平均74.9个）。组织病理学研究表明，从免疫猪身上获得的幼虫中，超过40%被完全破坏，其他的则处于不同的退化阶段。观察到嗜酸性粒细胞和单核细胞浸润幼虫的内部结构。嗜酸性粒细胞、淋巴细胞、巨噬细胞、上皮样细胞、浆细胞和成纤维细胞发生强烈的肉芽肿反应，包围着幼虫。对照猪的幼虫完整，周围有轻微的炎症反应。通过巨噬细胞移动抑制试验测定细胞反应，在感染猪带绦虫虫卵之前或屠宰之前，免疫猪的细胞反应均高于对照动物。免疫猪和对照猪的体液反应未发现显著差异。
