Molinari J L, Meza R, Tato P
Exp Parasitol. 1983 Dec;56(3):327-38. doi: 10.1016/0014-4894(83)90078-4.
In hogs naturally infected with Taenia solium larvae (i.e., Cysticercus cellulosae), we studied the host response induced by antigens obtained from the larvae. Histopathological studies of cysticerci removed after 4 and 8 weeks of immunization showed an intense inflammatory reaction surrounding the larvae. The response was greater in the 8-week specimens. A dense layer of eosinophils was in close contact with the external membrane of the bladder wall and, in several cases, the eosinophils had infiltrated this tegument. Many eosinophils were seen in the spiral canal of larvae. This infiltration by eosinophils increased with time. Preparations from the 8-week samples showed many degenerated and disrupted eosinophils whose granules were found in close contact with the outer membrane of the larval tegument and, in some cases, had entered through the broken surface of this structure. More than 90% of the larvae were found in various stages of degeneration; the rest were completely destroyed and surrounded by a mass of eosinophils. After immunization, peripheral blood eosinophilia increased to 17%, whereas the eosinophilia of the control hog was 4% throughout the study. The larval worms removed from control hogs showed intact structures, with a low degree of infiltration by eosinophils and a discrete inflammatory reaction surrounding the bladder wall of the larvae.
在自然感染有猪带绦虫幼虫（即猪囊尾蚴）的猪中，我们研究了从幼虫中获得的抗原所诱导的宿主反应。免疫4周和8周后取出的囊尾蚴的组织病理学研究显示，幼虫周围有强烈的炎症反应。8周标本中的反应更强。一层密集的嗜酸性粒细胞与膀胱壁的外膜紧密接触，在一些情况下，嗜酸性粒细胞已浸润到该皮层中。在幼虫的螺旋管中可见许多嗜酸性粒细胞。嗜酸性粒细胞的这种浸润随时间增加。8周样本的制剂显示许多嗜酸性粒细胞退化和破裂，其颗粒与幼虫皮层的外膜紧密接触，在某些情况下，已通过该结构的破损表面进入。超过90%的幼虫处于不同程度的退化阶段；其余的则被完全破坏并被大量嗜酸性粒细胞包围。免疫后，外周血嗜酸性粒细胞增多至17%，而在整个研究过程中，对照猪的嗜酸性粒细胞增多率为4%。从对照猪中取出的幼虫显示结构完整，嗜酸性粒细胞浸润程度低，幼虫膀胱壁周围有离散的炎症反应。
