Voĭnov V A, Chichenkov O N
Farmakol Toksikol. 1983 Mar-Apr;46(2):31-6.
It has been demonstrated in experiments on rabbits that anesthetic ether sodium thiopental, phentanyl and leucine-enkephalin have different inhibitory effects on the activity of inspiratory and expiratory neurons in the medulla oblongata. Bemegrid recovers the activity of the respiratory center inhibited by all the substances under study whereas naloxone eliminates apnea induced by phentanyl or leucine-encephalin alone. Besides, it has been ascertained that naloxone effectively abolishes the inhibition of the respiratory center caused by hyperventilation in rats.
在对兔子的实验中已证明,麻醉乙醚、硫喷妥钠、芬太尼和亮氨酸脑啡肽对延髓吸气和呼气神经元的活动有不同的抑制作用。贝美格可恢复被所有研究物质抑制的呼吸中枢的活动,而纳洛酮可消除仅由芬太尼或亮氨酸脑啡肽引起的呼吸暂停。此外,已确定纳洛酮可有效消除大鼠过度通气引起的呼吸中枢抑制。