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胃癌的肠型和弥漫型(作者译)

[The intestinal and diffuse type of the gastric carcinoma (author's transl)].

作者信息

Heilmann K, Burkhardt H U, Kayser K

出版信息

Z Gastroenterol. 1978 Jul;16(7):422-30.

PMID:685339
Abstract

According to the Laurén classification 357 carcinomas of the stomach were reclassified into intestinal and diffuse types. 58.2% were assigned to the intestinal type, 37.5% to the diffuse and 4% to a "mixed" group. There is obvious correlation between the intestinal type, the patients' advancing age and the incidence of chronic, atrophising gastritis with intestinal metaplasia. The diffuse type on the other hand occurs irrespective of gastric changes - mostly in younger persons. The intestinal type of gastric carcinoma frequently is found in risk areas where incidence is "epidemic" in nature; morphology and genetic origin seem to be gastric mucosa changes and intestinal metaplasia or dysplasia. Classifying gastric carcinoma according to Laurén (two groups) is also an appropriate method in our regions as was confirmed by the results we obtained; it is superior to the much more differentiated macro- and microscopic classifications used so far. Because of its simplicity, it is better suited for epidemiological and pathogenetic studies of the gastric carcinoma.

摘要

根据劳伦分类法,357例胃癌被重新分类为肠型和弥漫型。58.2%被归为肠型,37.5%为弥漫型,4%为“混合型”。肠型与患者年龄增长以及慢性萎缩性胃炎伴肠化生的发生率之间存在明显关联。另一方面,弥漫型的发生与胃部变化无关,多见于年轻人。肠型胃癌常见于发病率呈“流行”态势的风险区域;其形态和基因起源似乎与胃黏膜变化以及肠化生或发育异常有关。根据劳伦分类法(两组)对胃癌进行分类在我们地区也是一种合适的方法,我们所获得的结果证实了这一点;它优于迄今为止使用的更为细致的大体和显微镜分类法。由于其简单性,它更适合用于胃癌的流行病学和发病机制研究。

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