Pressey A, Watt B, Sharp D, Brown F V, Lambert H P
J Antimicrob Chemother. 1983 Apr;11(4):339-47. doi: 10.1093/jac/11.4.339.
Erythromycin and gentamicin were used to analyse the concept of bacterial synergy in an experimental model of acute appendicitis. Erythromycin given orally suppressed the aerobic flora other than the Enterobacteriaceae. When given by injection, a notable reduction in the counts of bacteroides and other anaerobic Gram-negative bacteria was also achieved. The addition of gentamicin, itself inactive against bacteroides, resulted in their total suppression. The implications of these findings are discussed.
在急性阑尾炎实验模型中，使用红霉素和庆大霉素来分析细菌协同作用的概念。口服红霉素可抑制肠杆菌科以外的需氧菌群。注射给药时，拟杆菌和其他厌氧革兰氏阴性菌的数量也显著减少。加入本身对拟杆菌无活性的庆大霉素后，可导致拟杆菌被完全抑制。讨论了这些发现的意义。
