Schriewer H, Günnewig V, Assmann G
J Clin Chem Clin Biochem. 1983 Mar;21(3):139-43. doi: 10.1515/cclm.1983.21.3.139.
In 138 men and 79 women sphingomyelin values in the supernatant of sera obtained by precipitation of apolipoprotein B-containing lipoproteins ( = high density lipoprotein-sphingomyelin, HDL sphingomyelin) were determined using an enzymatic method. In men, lower HDL sphingomyelin values were obtained (0.22 +/- 0.06 mmol/l) than for women (0.24 +/- 0.05 mmol/l) (p less than 0.05). In both sexes HDL sphingomyelin values were independent of age, with the exception that in men greater than or equal to 55 years, HDL sphingomyelin concentrations were lower. The correlation coefficients calculated for HDL sphingomyelin and hypertriglyceridaemia and relative body weight were lower than the correlation coefficients calculated for the corresponding HDL cholesterol values and both risk factors. In women with hypertriglyceridaemia (greater than or equal to 2.28 mmol/l) HDL sphingomyelin values were lower than those for normotriglyceridaemic women within the same age group, while in male hypertriglyceridaemic patients within the same age group there were no differences in HDL sphingomyelin values in comparison to normotriglyceridaemic male subjects. In both sexes the differences measured between hypertriglyceridaemic and normotriglyceridaemic subjects for HDL sphingomyelin were lower than for the corresponding HDL cholesterol values. The results obtained show that HDL sphingomyelin values are not simply a reflection of HDL cholesterol values.
采用酶法测定了138名男性和79名女性通过沉淀含载脂蛋白B的脂蛋白所获得的血清上清液中的鞘磷脂值（即高密度脂蛋白 - 鞘磷脂，HDL鞘磷脂）。男性的HDL鞘磷脂值（0.22±0.06 mmol/l）低于女性（0.24±0.05 mmol/l）（p＜0.05）。在两性中，HDL鞘磷脂值均与年龄无关，但55岁及以上男性的HDL鞘磷脂浓度较低。计算得出的HDL鞘磷脂与高甘油三酯血症及相对体重的相关系数低于相应的HDL胆固醇值与这两个风险因素的相关系数。在高甘油三酯血症女性（≥2.28 mmol/l）中，同一年龄组内其HDL鞘磷脂值低于正常甘油三酯血症女性，而在同一年龄组的男性高甘油三酯血症患者中，与正常甘油三酯血症男性相比，HDL鞘磷脂值无差异。在两性中，高甘油三酯血症和正常甘油三酯血症受试者之间HDL鞘磷脂的差异均低于相应的HDL胆固醇值。所得结果表明，HDL鞘磷脂值并非仅仅是HDL胆固醇值的反映。
