Moberg B, Wallentin L
Eur J Clin Invest. 1981 Dec;11(6):433-40. doi: 10.1111/j.1365-2362.1981.tb02010.x.
The aim was to investigate whether a low concentration of high density lipoprotein (HDL) may be used as a risk indicator in normolipidaemic (n.l.) subjects, and whether a reduced HDL concentration constitutes an additional risk factor in hyperlipoproteinaemia. Eighty-two men with angiographically documented coronary artery disease (CAD) were studied. The majority of the CAD men was either n.l. (n = 38) or had type IV hyperlipoproteinaemia (n = 22). These two groups were compared separately to one group of healthy n.l. subjects (n = 44), and one group of healthy subjects with type IV hyperlipoproteinaemia (n = 29). In about 50% of n.l. CAD men the HDL-cholesterol (HDL-C) was lower than the 15th percentile (0.90 mmol/l) of n.l. controls, and about 65% of n.l. CAD men had ratios of HDL-C/total plasma cholesterol (C) lower than 0.17, the 15th percentile of n.l. controls. Almost all type IV subjects had reduced HDL-C levels and decreased ratios of HDL-C/C, whether they had obvious CAD or not. Thus, in normolipidaemia, but not in type IV hyperlipoproteinaemia, a low HDL-C level may be used as an additional risk factor for CAD development.
目的是研究低浓度的高密度脂蛋白（HDL）是否可作为血脂正常（n.l.）受试者的风险指标，以及HDL浓度降低是否构成高脂蛋白血症的额外风险因素。对82名经血管造影证实患有冠状动脉疾病（CAD）的男性进行了研究。大多数CAD男性要么血脂正常（n = 38），要么患有IV型高脂蛋白血症（n = 22）。将这两组分别与一组健康的血脂正常受试者（n = 44）和一组患有IV型高脂蛋白血症的健康受试者（n = 29）进行比较。在约50%的血脂正常的CAD男性中，HDL胆固醇（HDL-C）低于血脂正常对照组的第15百分位数（0.90 mmol/l），约65%的血脂正常的CAD男性的HDL-C/总血浆胆固醇（C）比值低于0.17，即血脂正常对照组的第15百分位数。几乎所有IV型受试者的HDL-C水平均降低，HDL-C/C比值均下降，无论他们是否有明显的CAD。因此，在血脂正常但非IV型高脂蛋白血症的情况下，低HDL-C水平可作为CAD发生的额外风险因素。
