Titov V N, Krauze E G, Filippov I K, Rabich G, Filippova V A
Kardiologiia. 1983 Mar;23(3):51-5.
The activity of glycogen phosphorylase (GP) and creatine phosphokinase isoenzyme MB (CPK MB) was measured in patients with myocardial infarction over 72 hours after the anginal attack. In most clinical observations, CPK MB and GP patterns were similar, however, the GP activity reached its peak 4-6 hours earlier, and sooner returned to normal, as compared to that of CPK MB. The measurement of GP and CPK MB activity at early dates of myocardial infarction provides more evidence of new lesion foci or expanding necrotic area. In one-third of the infarction patients, the said enzymes showed different patterns of activity. It is suggested that the assessment of GP and CPK MB activity in cases of myocardial infarction may contribute to better insight into both necrotic and ischemic myocardial processes associated with myocardial infarction, with similar trends in enzyme patterns indicating necrotic myocardial changes, and high GP activity coupled with unchanged CPK MB signalling myocardial ischemia.
在心绞痛发作72小时后，对心肌梗死患者的糖原磷酸化酶（GP）和肌酸磷酸激酶同工酶MB（CPK MB）活性进行了测定。在大多数临床观察中，CPK MB和GP模式相似，然而，与CPK MB相比，GP活性提前4 - 6小时达到峰值，且更快恢复正常。在心肌梗死早期测定GP和CPK MB活性，可为新的病变灶或扩大的坏死区域提供更多证据。在三分之一的梗死患者中，上述酶显示出不同的活性模式。建议在心肌梗死病例中评估GP和CPK MB活性，可能有助于更好地洞察与心肌梗死相关的坏死和缺血性心肌过程，酶模式的相似趋势表明坏死性心肌变化，而高GP活性与CPK MB不变则提示心肌缺血。
