Liusov V A, Orlov S N, Postnov I Iu, Kharchenko V I
Kardiologiia. 1983 Mar;23(3):76-80.
Sodium transport was investigated, using the isotope exchange method, in the erythrocyte membranes of normal subjects and patients with essential and symptomatic (renal) hypertension. In hypertensive patients, the constant of balanced Na/Na exchange rate was increased by more than 60%, and the balance concentration of erythrocytic sodium by 30%, as compared to the controls, in the presence of ouabain. These differences become far less pronounced if furosemide is added to the incubation medium. In patients with secondary (renal) hypertension, the Na/Na exchange rate and erythrocytic balance concentration of sodium are not affected by ouabain as compared to the controls. It is suggested that Na/Na-countertransport plays the principal role in the disruption of erythrocyte membrane permeability by sodium in essential hypertension.
采用同位素交换法，对正常受试者以及原发性和症状性（肾性）高血压患者的红细胞膜钠转运情况进行了研究。在存在哇巴因的情况下，与对照组相比，高血压患者的钠/钠平衡交换率常数增加了60%以上，红细胞钠平衡浓度增加了30%。如果在孵育培养基中加入呋塞米，这些差异就会变得不那么明显。与对照组相比，继发性（肾性）高血压患者的钠/钠交换率和红细胞钠平衡浓度不受哇巴因影响。有人提出，在原发性高血压中，钠/钠逆向转运在钠破坏红细胞膜通透性过程中起主要作用。
