Mahoney A W, Hendricks D G, Bernhard N, Sisson D V
Pharmacol Biochem Behav. 1983 May;18(5):683-7. doi: 10.1016/0091-3057(83)90006-0.
Because fasting and ketogenic diets decrease seizure susceptibility in epileptics, their anticonvulsant effects were studied using sound-induced seizures in the magnesium-deficient rat. Fasting markedly depressed seizure incidence and severity but did not affect latency (sec to seizure onset). High-fat diet increased incidence of audiogenic seizures and seizure severity, and decreased latency. Gavage of medium chain triglyceride, beta-hydroxybutyrate or glucose did not affect seizure incidence, seizure severity or latency. Nonspecific excitability level was not associated with treatment nor with seizure incidence, severity or latency time.
由于禁食和生酮饮食可降低癫痫患者的癫痫易感性，因此我们利用缺镁大鼠的声音诱发癫痫来研究它们的抗惊厥作用。禁食显著降低了癫痫发作的发生率和严重程度，但不影响潜伏期（癫痫发作开始的秒数）。高脂饮食增加了听源性癫痫的发生率和癫痫严重程度，并缩短了潜伏期。灌胃中链甘油三酯、β-羟基丁酸或葡萄糖对癫痫发作的发生率、严重程度或潜伏期没有影响。非特异性兴奋水平与治疗无关，也与癫痫发作的发生率、严重程度或潜伏时间无关。
