Hulth A, Johnell O
Acta Orthop Scand. 1978 Jun;49(3):240-3. doi: 10.3109/17453677809005758.
Injection of a single dose of an antigenic substance (sheep red blood corpuscles) in young rats results in a significant rise in the number of mitoses in bone marrow (and in thymus) and in addition a significant rise in the number of osteoclasts in the metaphyses of the ribs. This increased osteoclasia appears 1 day after the peak values of the bone marrow and thymus mitoses. This and earlier investigations make it probable that there is a causal relationship between bone marrow stimulation and increased osteoclasia.
给幼鼠注射单剂量抗原物质（绵羊红细胞）会导致骨髓（和胸腺）中细胞有丝分裂数量显著增加，此外，肋骨干骺端破骨细胞数量也会显著增加。这种破骨细胞增多现象在骨髓和胸腺有丝分裂达到峰值后的1天出现。本次研究及早期研究表明，骨髓刺激与破骨细胞增多之间可能存在因果关系。
