Otsuki Y, Yamaji K, Fujita M, Takagi T, Tanizawa O
Acta Obstet Gynecol Scand. 1983;62(1):15-8. doi: 10.3109/00016348309155750.
Maternal plasma oxytocin levels during pregnancy and labor were measured by a sensitive and specific radio-immunoassay. The mean plasma oxytocin concentration in maternal peripheral plasma showed a gradual rise towards term, reaching 12.5 microU/ml in term subjects without labor contractions. This level was not significantly different from the mean value in the 1st stage of normal spontaneous labor (12.6 microU/ml). Brief fluctuations in plasma oxytocin levels of considerable degree, and sometimes spurt release, were observed in labor and at term, but not in the mid-trimester, in serial samples collected at short intervals (about 10 sec). In normal spontaneous labor, no obvious relation was observed between the plasma oxytocin level and the uterine contraction period, and no significant difference was found between the mean value in uterine contraction periods (12.1 microU/ml) and that in relaxation periods (11.5 microU/ml).
采用灵敏且特异的放射免疫分析法测定孕期及分娩期母体血浆中的催产素水平。母体外周血浆中催产素的平均浓度在足月时呈逐渐上升趋势，在未出现宫缩的足月孕妇中达到12.5微国际单位/毫升。该水平与正常自然分娩第一产程的平均值（12.6微国际单位/毫升）无显著差异。在短时间间隔（约10秒）采集的系列样本中，观察到分娩期和足月时血浆催产素水平有相当程度的短暂波动，有时会出现突发释放，但孕中期未出现这种情况。在正常自然分娩中，未观察到血浆催产素水平与子宫收缩期之间存在明显关联，子宫收缩期的平均值（12.1微国际单位/毫升）与松弛期的平均值（11.5微国际单位/毫升）之间也未发现显著差异。
