Hollstedt C, Dahlgren L, Rydberg U
Acta Psychiatr Scand. 1983 Apr;67(4):236-48. doi: 10.1111/j.1600-0447.1983.tb06737.x.
The studies in man concerning foetal alcohol damage have mostly covered skid row female alcoholics, and no study has described the outcome of pregnancy of a larger group of women receiving inpatient care for alcoholism. In another study we have described the medical and social characteristics of such a group (n = 92) of women, as well as those of an age-matched control group. This article reports retrospectively on the pregnancies and the infants of these women. The pregnancies and deliveries were normal in both groups. There was no significant difference in rate of stillbirths, neonatal mortality, perinatal asphyxia or neonatal distress. In infants born to alcoholic mothers after established regular alcohol consumption (n = 31), a significant reduction of mean placental weight, birth weight, length at birth and head circumference at birth, was found compared with control infants (n = 170). In the former group 12.9% of the infants were small for gestational age, in the latter 1.3%. Congenital malformations were significantly increased in the former group. Thus, in female inpatients at an alcohol clinic a history of increased risk for adverse neonatal outcome was found.
关于胎儿酒精损伤的人体研究大多针对贫民窟的女性酗酒者，尚无研究描述接受住院治疗的更多酗酒女性群体的妊娠结局。在另一项研究中，我们描述了这样一组（n = 92）女性以及与之年龄匹配的对照组的医学和社会特征。本文回顾性报道了这些女性的妊娠情况及所生婴儿的情况。两组的妊娠和分娩过程均正常。死产率、新生儿死亡率、围产期窒息或新生儿窘迫方面均无显著差异。与对照组婴儿（n = 170）相比，在有规律饮酒习惯后怀孕的酗酒母亲所生婴儿（n = 31）中，平均胎盘重量、出生体重、出生时身长和出生时头围均显著降低。前一组中12.9%的婴儿为小于胎龄儿，后一组为1.3%。前一组先天性畸形显著增加。因此，在酒精诊所的女性住院患者中发现了不良新生儿结局风险增加的情况。
