Damerau B, Keller H U
Agents Actions. 1983 Feb;13(1):53-8. doi: 10.1007/BF01994282.
C5adesArg-induced leucocyte aggregation and neutrophil adhesion to glass were compared using the same cell separation technique and identical chemicals for preparing the media. Human serum albumin decreased adhesion to glass but had no effect on leucocyte aggregation induced by C5adesArg. In contrast, C5adesArg in Gey's solution with or without HSA, in serum or plasma stimulated leucocyte aggregation in a dose-dependent fashion. However, it did not alter neutrophil adhesion to glass. This indicates that leucocyte aggregation and neutrophil adherence to glass do not necessarily represent equivalent responses taking place on different substrata. Thus they may be mechanistically distinct.
使用相同的细胞分离技术和制备培养基的相同化学物质，比较了C5adesArg诱导的白细胞聚集和中性粒细胞对玻璃的黏附。人血清白蛋白降低了对玻璃的黏附，但对C5adesArg诱导的白细胞聚集没有影响。相比之下，在含有或不含有HSA的Gey溶液中、血清或血浆中的C5adesArg以剂量依赖性方式刺激白细胞聚集。然而，它并没有改变中性粒细胞对玻璃的黏附。这表明白细胞聚集和中性粒细胞对玻璃的黏附不一定代表在不同底物上发生的等效反应。因此，它们在机制上可能是不同的。
