Majewski S, Wasik M, Jabłońska S, Kamiński M, Fraczykowska M
Arch Dermatol Res. 1986;278(4):264-9. doi: 10.1007/BF00407735.
Patients (n = 45) with psoriasis vulgaris were studied for natural killer (NK) cell activity and antibody-dependent cell cytotoxicity (ADCC) of their peripheral blood mononuclear cells against K-562 and L1210 target cells, respectively. Simultaneously, the studies were performed on the adherence to human endothelium of polymorphonuclear leukocytes (PMN) from various forms of the disease. Mean values of NK-cell activity in psoriasis vulgaris, as a whole, and mean values of ADCC in male patients were significantly lower than in a group of healthy controls. This decrease was most pronounced in patients with the active form of the disease, in whom in vitro PMN adherence to human endothelium was found to be increased. Neutrophils from both patients with active psoriasis and healthy individuals were capable of reducing NK-cell activity of normal human mononuclear cells.
对45例寻常型银屑病患者外周血单个核细胞针对K-562和L1210靶细胞的自然杀伤（NK）细胞活性及抗体依赖性细胞毒性（ADCC）进行了研究。同时，对不同疾病形式患者的多形核白细胞（PMN）与人内皮细胞的黏附情况进行了研究。总体而言，寻常型银屑病患者的NK细胞活性平均值以及男性患者的ADCC平均值显著低于健康对照组。这种降低在疾病活动期患者中最为明显，这些患者体外PMN与人内皮细胞的黏附增加。活动期银屑病患者和健康个体的中性粒细胞均能够降低正常人单核细胞的NK细胞活性。
