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[钕钇铝石榴石激光照射猪主动脉的定性和定量效应及其与血管成形术的关系]

[Qualitative and quantitative effects of neodymium YAG laser irradiation of the aortas of swine with reference to angioplasty].

作者信息

Wollenek G, Laufer G, Wolner E

出版信息

Langenbecks Arch Chir. 1985;367(1):3-10. doi: 10.1007/BF01241940.

Abstract

During last few years the concept of vaporizing atheromatous plaques and thrombotic occlusions by laser energy arose. This method is a new and possibly valuable modality in the treatment of obstructive vascular diseases. We used a continuous 1,060 nm Nd-YAG laser with a focused optical wave guide. Sections of porcine aortic vessels were split longitudinally and exposed to laser radiation. Four major types of tissue alterations were observed: local swelling, disruption of the inner layers of the vessel wall, charred punched-out defects and wall perforation. Histologic examination revealed a typical damage pattern as a result of thermic injury. Clean tissue alteration is the desired effect for angioplasty. The thermic alterations limit the applicability when dealing with the cw Nd-YAG laser for this purpose.

摘要

在过去几年中,出现了利用激光能量汽化动脉粥样硬化斑块和血栓性闭塞的概念。这种方法是治疗阻塞性血管疾病的一种新的且可能有价值的方式。我们使用了带有聚焦光导的连续1060纳米钕钇铝石榴石激光。将猪主动脉血管切片纵向切开并暴露于激光辐射下。观察到四种主要类型的组织改变:局部肿胀、血管壁内层破坏、烧焦的穿孔缺损和血管壁穿孔。组织学检查显示出热损伤导致的典型损伤模式。清洁的组织改变是血管成形术所期望的效果。在为此目的使用连续波钕钇铝石榴石激光时,热改变限制了其适用性。

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