Wollenek G, Laufer G, Wolner E
Langenbecks Arch Chir. 1985;367(1):3-10. doi: 10.1007/BF01241940.
During last few years the concept of vaporizing atheromatous plaques and thrombotic occlusions by laser energy arose. This method is a new and possibly valuable modality in the treatment of obstructive vascular diseases. We used a continuous 1,060 nm Nd-YAG laser with a focused optical wave guide. Sections of porcine aortic vessels were split longitudinally and exposed to laser radiation. Four major types of tissue alterations were observed: local swelling, disruption of the inner layers of the vessel wall, charred punched-out defects and wall perforation. Histologic examination revealed a typical damage pattern as a result of thermic injury. Clean tissue alteration is the desired effect for angioplasty. The thermic alterations limit the applicability when dealing with the cw Nd-YAG laser for this purpose.
在过去几年中，出现了利用激光能量汽化动脉粥样硬化斑块和血栓性闭塞的概念。这种方法是治疗阻塞性血管疾病的一种新的且可能有价值的方式。我们使用了带有聚焦光导的连续1060纳米钕钇铝石榴石激光。将猪主动脉血管切片纵向切开并暴露于激光辐射下。观察到四种主要类型的组织改变：局部肿胀、血管壁内层破坏、烧焦的穿孔缺损和血管壁穿孔。组织学检查显示出热损伤导致的典型损伤模式。清洁的组织改变是血管成形术所期望的效果。在为此目的使用连续波钕钇铝石榴石激光时，热改变限制了其适用性。
