Noller K L, Townsend D E, Kaufman R H, Barnes A B, Robboy S J, Fish C R, Jefferies J A, Bergstralh E J, O'Brien P C, McGorray S P, Scully R
Am J Obstet Gynecol. 1983 Jun 1;146(3):279-85. doi: 10.1016/0002-9378(83)90749-4.
A total of 452 women with documented exposure in utero to diethylstilbestrol (DES) with epithelial findings present at the time of their initial examination have been evaluated prospectively to determine whether these findings changed over a period of 3 years. The examinations were all performed according to a strict protocol. Findings present at the time of the third annual examination were verified at a fourth examination. A verified decrease in the extent of epithelial findings occurred in 29.2% of these women and a verified increase in 6.6%; 53.1% had no change in the extent of epithelial findings, and 11.1% had a change that could not be verified at the time of the fourth visit. Analysis of many variables failed to identify a strong association between any variable and a decrease in the extent of the findings. It appears that the most important factor in the occurrence of changes in DES-associated findings is the passage of time.
共有452名在子宫内有己烯雌酚（DES）暴露记录且在初次检查时有上皮组织检查结果的女性接受了前瞻性评估，以确定这些检查结果在3年时间里是否发生变化。所有检查均按照严格方案进行。第三次年度检查时出现的检查结果在第四次检查时得到核实。在这些女性中，经核实上皮组织检查结果范围下降的占29.2%，上升的占6.6%；53.1%上皮组织检查结果范围无变化，11.1%有变化但在第四次就诊时无法核实。对诸多变量的分析未能确定任何变量与检查结果范围缩小之间存在强关联。看来，与DES相关的检查结果发生变化的最重要因素是时间的推移。
