Rolfe B E, Morton H, Cavanagh A C, Gardiner R A
Am J Reprod Immunol (1980). 1983 Mar;3(2):97-100. doi: 10.1111/j.1600-0897.1983.tb00223.x.
Early pregnancy factor (EPF) is produced by both maternal and fetal tissue1,2 and has been detected previously only during pregnancy.3,4 The present report describes the detection of EPF, or an EPF-like substance (tEPF), in serum from patients with germ cell tumors of the testis. tEPF, or its free components, tEPF-A and tEPF-B, were detected in all 11 patients with nonseminomatous tumors and in 5 of 10 patients with seminoma. It was not detected in serum from healthy male controls nor in patients with non-germ cell tumors or benign testicular disease. It is suggested that tEPF may be an additional serum marker for germ cell tumors and may expand the group already detectable by such markers.
早孕因子（EPF）由母体和胎儿组织共同产生，此前仅在孕期被检测到。本报告描述了在睾丸生殖细胞瘤患者血清中检测到EPF或类EPF物质（tEPF）。在11例非精原细胞瘤患者以及10例精原细胞瘤患者中的5例血清中检测到了tEPF或其游离成分tEPF-A和tEPF-B。在健康男性对照者血清以及非生殖细胞瘤或睾丸良性疾病患者血清中未检测到。提示tEPF可能是生殖细胞瘤的一种额外血清标志物，并且可能扩大此类标志物已能检测的范围。
