一系列双吡啶的结构与抗牙菌斑及抗菌活性之间的关系
Relationship between structure and antiplaque and antimicrobial activities for a series of bispyridines.
作者信息
Slee A M, O'Connor J R, Bailey D M
出版信息
Antimicrob Agents Chemother. 1983 Apr;23(4):531-5. doi: 10.1128/AAC.23.4.531.
Abstract
A series of bispyridines were examined for their bactericidal activities against in vitro, preformed, pure-culture plaques of selected oral plaque-forming bacteria. The antimicrobial activities of these agents were examined in relation to their molecular configurations. These studies demonstrated that the length of the interpyridine polymethylene group bridge and the length of the alkyl side chain were important determinants of antiplaque and antimicrobial efficacy. The most potent compounds of the bispyridine series were studied to determine the minimal conditions (concentration, duration, and frequency) of treatment required for likely clinical efficacy.
摘要
对一系列联吡啶进行了研究，考察它们对体外预先形成的、选定的口腔菌斑形成细菌纯培养菌斑的杀菌活性。研究了这些药剂的抗菌活性与其分子构型的关系。这些研究表明，联吡啶聚亚甲基桥的长度和烷基侧链的长度是抗菌斑和抗菌效果的重要决定因素。对联吡啶系列中最有效的化合物进行了研究，以确定可能具有临床疗效所需的最低治疗条件（浓度、持续时间和频率）。
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