Slee A M, O'Connor J R
Antimicrob Agents Chemother. 1983 Mar;23(3):379-84. doi: 10.1128/AAC.23.3.379.
The antibacterial activity of octenidine dihydrochloride (WIN 41464-2) against intact preformed in vitro plaques of four indigenous oral plaque-forming microorganisms, Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus, and Actinomyces naeslundii, was studied. Both absolute (plaque bactericidal index) and relative (chlorhexidine coefficient) indices of antiplaque efficacy were established. Octenidine dihydrochloride compared favorably with chlorhexidine digluconate with respect to overall antiplaque potency in this in vitro plaque bactericidal model. These data indicate that prudent selection of treatment concentration and duration and frequency of exposure should provide an effective means to aid in controlling dental caries and Actinomyces-associated disease in vivo.
研究了二盐酸奥替尼啶（WIN 41464-2）对四种口腔固有菌斑形成微生物——变形链球菌、血链球菌、粘性放线菌和内氏放线菌完整的体外预成菌斑的抗菌活性。建立了抗菌斑效果的绝对指标（菌斑杀菌指数）和相对指标（洗必泰系数）。在这个体外菌斑杀菌模型中，就整体抗菌斑效力而言，二盐酸奥替尼啶与葡萄糖酸洗必泰相比具有优势。这些数据表明，谨慎选择治疗浓度、暴露持续时间和频率应能提供一种有效的手段，有助于在体内控制龋齿和放线菌相关疾病。
