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Cystathionase: a potential cytoplasmic marker of hematopoietic differentiation.

作者信息

Link D, Drebing C, Glode L M

出版信息

Blut. 1983 Jul;47(1):31-9. doi: 10.1007/BF00321048.

DOI:10.1007/BF00321048
PMID:6860801
Abstract

Cysteine auxotrophy and absence of cystathionase (CSE) has been associated with certain human and rodent leukemic cell lines. To determine whether this state was a marker of malignant transformation or of cellular differentiation, CSE content was measured in 16 well characterized human leukemia-lymphoma cell lines. Enzyme was easily detected in several lines but its level did not correlate with a proposed scheme of differentiation based on cell-surface markers. However, the apparent absence of enzyme in human bone marrow CFU-C determined by growth experiments suggests reduced levels of CSE may be a marker of cytoplasmic immaturity.

摘要

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Cystathionase: a potential cytoplasmic marker of hematopoietic differentiation.
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本文引用的文献

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Cysteine auxotrophy of human leukemic lymphoblasts is associated with decreased amounts of intracellular cystathionase protein.人类白血病淋巴母细胞的半胱氨酸营养缺陷与细胞内胱硫醚酶蛋白量的减少有关。
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