Brainard G C, Richardson B A, King T S, Matthews S A, Reiter R J
Endocrinology. 1983 Jul;113(1):293-6. doi: 10.1210/endo-113-1-293.
The purpose of this study was to test the influence of various irradiances of cool white fluorescent light on the suppression of pineal N-acetyltransferase activity (NAT) and melatonin content in hamsters. Groups of animals were exposed to light irradiances ranging from 0.00-1.86 microwatts (microW)/cm2 for 20 min during the night. Both pineal NAT and melatonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED50 for NAT (0.066 microW/cm2) and melatonin (0.058 microW/cm2) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination.
本研究的目的是测试不同辐照度的冷白色荧光灯对仓鼠松果体N - 乙酰转移酶活性（NAT）和褪黑素含量抑制的影响。将动物分组，在夜间暴露于0.00 - 1.86微瓦（μW）/平方厘米的光照辐照度下20分钟。松果体NAT和褪黑素均以剂量相关的方式被光照辐照度类似地抑制。所得剂量反应曲线的形状以及计算出的NAT（0.066μW/平方厘米）和褪黑素（0.058μW/平方厘米）的半数有效剂量（ED50）非常相似。这些发现可能与自然光照对松果体的生理控制有关。
