76千道尔顿的聚腺苷酸结合蛋白参与48S起始复合物的形成。
76-kDa poly(A)-protein is involved in the formation of 48 S initiation complexes.
作者信息
Schmid H P, Schönfelder M, Setyono B, Köhler K
出版信息
FEBS Lett. 1983 Jun 27;157(1):105-10. doi: 10.1016/0014-5793(83)81125-9.
In erythropoietic mouse cells induced by Friend leukemia virus, approximately 50% of non-polyribosomal globin mRNA is found in 48 S initiation complexes ready to be translated. EDTA releases 15 S globin mRNPs, homologous to polyribosomal globin mRNPs. The 76-kDa poly(A)-protein is one of its main protein components. The other 50% of non-polyribosomal message can be separated as 20 S 'free' mRNPs. Its protein composition is different, especially the 76-kDa protein is lacking. The role of this protein is discussed.
在由弗瑞德白血病病毒诱导的红细胞生成小鼠细胞中，约50%的非多核糖体珠蛋白mRNA存在于准备翻译的48S起始复合物中。乙二胺四乙酸（EDTA）释放出与多核糖体珠蛋白mRNP同源的15S珠蛋白mRNP。76 kDa的聚腺苷酸结合蛋白是其主要蛋白质成分之一。另外50%的非多核糖体信息可分离为20S“游离”mRNP。其蛋白质组成不同，尤其是缺少76 kDa的蛋白质。本文讨论了这种蛋白质的作用。
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