磷酸烯醇丙酮酸穿梭——能量从线粒体到细胞质的转运。
Phosphoenolpyruvate shuttle--transport of energy from mitochondria to cytosol.
作者信息
Drahota Z, Rauchová H, Miková M, Kaul P, Bass A
出版信息
FEBS Lett. 1983 Jul 4;157(2):347-9. doi: 10.1016/0014-5793(83)80573-0.
Brown-adipose tissue mitochondria of hamster and rat contain phosphoenolpyruvate carboxykinase (EC 4.1.1.32). In the presence of ketoglutarate and malate, phosphoenolpyruvate is formed and exported from mitochondria. Phosphoenolpyruvate formation is inhibited by 1,2,3-benzenetricarboxylate. It is proposed that phosphoenolpyruvate carboxykinase together with pyruvate carboxylase and pyruvate kinase forms a phosphoenolpyruvate shuttle through which energy produced by the Krebs cycle in mitochondria may be exported to cytosol.
仓鼠和大鼠的棕色脂肪组织线粒体含有磷酸烯醇式丙酮酸羧激酶（EC 4.1.1.32）。在存在酮戊二酸和苹果酸的情况下，磷酸烯醇式丙酮酸形成并从线粒体输出。磷酸烯醇式丙酮酸的形成受到1,2,3-苯三甲酸的抑制。有人提出，磷酸烯醇式丙酮酸羧激酶与丙酮酸羧化酶和丙酮酸激酶一起形成一个磷酸烯醇式丙酮酸穿梭途径，通过该途径线粒体中三羧酸循环产生的能量可以输出到细胞质中。
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