Schwartz P E, MacLusky N, Sakamoto H, Eisenfeld A
Gynecol Oncol. 1983 Jun;15(3):305-15. doi: 10.1016/0090-8258(83)90048-3.
Tissue samples from 20 patients with nonepithelial ovarian malignancies were assayed for cytosol estrogen (ERc) and in selected samples progestin-receptor (PRc) proteins. The nine germ cell malignancies assayed were low in ERc. One recurrent granulosa cell tumor had an ERc concentration of 36 fmole/mg cytosol protein (fmole/mg c.p.) while three other stromal tumors were low in ERc. Three of seven mixed mesodermal tumors had a high ERc concentration (34-91 fmole/c.p.). Two primary and one recurrent granulosa cell tumors and one endodermal sinus tumor had borderline to elevated PRc levels (18-254 fmole/c.p.). Four of seven mixed mesodermal tumors had borderline to slightly elevated PRc concentrations (13-22 fmole/c.p.). The low ERc in germ cell malignancies of the ovary is consistent with previous clinical observations that the growth of these tumors is not influenced by removal of the contralateral ovary. The high ERc levels detected in three of seven mixed mesodermal ovarian tumors and one of three granulosa cell tumors suggest that hormone-related therapy should be investigated in the management of patients with these malignancies.
对20例非上皮性卵巢恶性肿瘤患者的组织样本进行了细胞溶质雌激素（ERc）检测，并在部分样本中检测了孕激素受体（PRc）蛋白。检测的9例生殖细胞恶性肿瘤的ERc水平较低。1例复发性颗粒细胞瘤的ERc浓度为36飞摩尔/毫克细胞溶质蛋白（fmole/mg c.p.），而其他3例间质瘤的ERc水平较低。7例混合性中胚层肿瘤中有3例的ERc浓度较高（34 - 91飞摩尔/c.p.）。2例原发性和1例复发性颗粒细胞瘤以及1例内胚窦瘤的PRc水平处于临界值至升高水平（18 - 254飞摩尔/c.p.）。7例混合性中胚层肿瘤中有4例的PRc浓度处于临界值至轻度升高水平（13 - 22飞摩尔/c.p.）。卵巢生殖细胞恶性肿瘤中ERc水平较低与先前的临床观察结果一致，即这些肿瘤的生长不受对侧卵巢切除的影响。在7例混合性中胚层卵巢肿瘤中的3例以及3例颗粒细胞瘤中的1例中检测到的高ERc水平表明，对于这些恶性肿瘤患者的治疗，应研究激素相关疗法。
