Reynolds J D, Morris B
Immunology. 1983 Jul;49(3):501-9.
The number and type of lymphoid cells in the intestinal mucosa of lambs change during the first weeks after birth. The influence of gut function on these changes was examined by comparing the evolution of lymphoid cell populations in normal ileum with that in lengths of ileum which had been isolated surgically from the functional intestinal tract of the lamb before birth. The isolated lengths of ileum had a normal blood and nerve supply and they remained healthy throughout a period of at least 2 years, although they did not have a normal histological development. In comparison with normal ileum, the villi of the isolated ileal segments were much smaller and there were many fewer intraepithelial lymphocytes; the lamina propria had significantly fewer lymphocytes than the functional ileum and only a few plasma cells. When isolated ileal segments were reconnected into the intestinal tract after having been isolated from it for 1-3 months, the histology of the mucosa reverted to that of the normal gut, with the same number and types of lymphoid cells. Radiolabelled lymphoblasts collected from intestinal lymph and injected intravenously accumulated to only a small extent in isolated segments of ileum compared with either the normal or the reconnected segments of ileum. This suggested that the paucity of lymphocytes in the mucosa of the isolated segments was due to a reduced extravasation of these cells there. The influence which the gut contents exert on the lymphoid cell population in the mucosa is probably associated with antigenic stimulation but may also be related to other factors concerned in the normal digestive functions of the gut.
羔羊出生后的最初几周内，其肠黏膜中淋巴细胞的数量和类型会发生变化。通过比较正常回肠与出生前从羔羊功能性肠道中手术分离出的回肠段中淋巴细胞群体的演变情况，研究了肠道功能对这些变化的影响。分离出的回肠段有正常的血液和神经供应，并且在至少2年的时间里一直保持健康，尽管它们没有正常的组织学发育。与正常回肠相比，分离出的回肠段绒毛要小得多，上皮内淋巴细胞也少得多；固有层中的淋巴细胞明显少于功能性回肠，且只有少数浆细胞。当分离出的回肠段在与肠道分离1 - 3个月后重新连接到肠道中时，黏膜的组织学恢复到正常肠道的状态，淋巴细胞的数量和类型相同。与正常回肠段或重新连接后的回肠段相比，从肠道淋巴中收集并静脉注射的放射性标记成淋巴细胞在分离出的回肠段中仅少量积聚。这表明分离出的回肠段黏膜中淋巴细胞数量稀少是由于这些细胞在那里的渗出减少。肠道内容物对黏膜中淋巴细胞群体的影响可能与抗原刺激有关，但也可能与肠道正常消化功能所涉及的其他因素有关。
