Gorrell M D, Willis G, Brandon M R, Lascelles A K
Department of Veterinary Preclinical Sciences, University of Melbourne, Parkville, Victoria, Australia.
Clin Exp Immunol. 1988 May;72(2):274-9.
Monoclonal antibodies to ovine lymphocyte surface antigens were used in an immunohistochemical study of the intestine of sheep. In the epithelium CD8+ cells predominated whereas the majority of lamina propria T lymphocytes were CD4+. Infection of sheep with the parasitic nematode Trichostrongylus colubriformis including sufficiently large numbers of parasites to induce protective immunity did not alter the number of CD4+ or CD8+ lymphocytes in the intestinal mucosa. In contrast, exposure of naive sheep to a single large infection of T. colubriformis resulted in a substantial decrease in number of CD8+ cells and moderate decreases in number of CD4+ cells in the duodenal but not the jejunal mucosa. MHC class II antigens were not detected either in or on epithelial cells of the sheep small intestine.
抗绵羊淋巴细胞表面抗原的单克隆抗体被用于绵羊肠道的免疫组织化学研究。在上皮中，CD8+细胞占主导，而固有层中的大多数T淋巴细胞是CD4+。用寄生线虫蛇形毛圆线虫感染绵羊，包括感染足够数量的寄生虫以诱导保护性免疫，并未改变肠黏膜中CD4+或CD8+淋巴细胞的数量。相反，将未感染过的绵羊暴露于单次大量蛇形毛圆线虫感染中，导致十二指肠而非空肠黏膜中CD8+细胞数量大幅减少，CD4+细胞数量适度减少。在绵羊小肠的上皮细胞内或其表面均未检测到MHC II类抗原。
